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lipoic acid glutathione reductase Alpha exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats redox behavior of alpha-lipoic acid
Description
95 LewisR

Alqahtani, S., Mohamed, L

10.1002/jbm.a.32711 78 LuoA.GeZ.FanY.LuoA.ChunZ.HeX

It should however be noted that Cys residues are used for a wide range of functions catalytic, regulatory, structural, and others whereas the related amino acid selenocysteine (Sec, further discussed below) seems to be uniquely dedicated to the catalysis of redox reactions [2932]

Asian J Andrology

This dual-target degradation profile directly correlates with the observed therapeutic efficacy, validating the assembly driven target engagement and degradation strategy