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ADD3 mutations disrupt afferent arteriole contractility by interfering with the actin cytoskeletal architecture, resulting in a loss of myogenic tone and increased glomerular capillary pressure, ultimately resulting in proteinuria and glomerulosclerosis in FHH rats

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You should see a doctor if you experience any new or worsening vision changes, such as: blurred vision dark spots flashes of light sudden vision loss For people without diabetes or without existing eye disease, eye-related side effects are considered very unlikely

Those findings are then evaluated through increasingly rigorous research before any clinical conclusions can be drawn