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Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes

[DOI] [PubMed] [Google Scholar] 52.Januszewicz E, Bekisz M, Mozrzymas JW, Nalecz KA

As the medicated hydrogel lenses are better at resisting clearance due to frequent blinking, permanent tear production (0.52.2 L min-1), [157], and nasolacrimal drainage than eye drops, [149], they allow drugs and biologics to penetrate the cornea more effectively and thus have been reported to enhance therapeutic effectiveness [158]

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doi:10.1126/science.aav9750 144
