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Clinical qualification: folic acid remains important for preventing neural-tube defects

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A relatively precise construction of an oriC plasmid based on the Replicon Theory was first achieved by Hirota's group by taking the oriC region (as defined by Worcel's group) to allow replication and combining it with a gene encoding ampicillin resistance to allow selection of the resultant plasmid (Yasuda and Hirota, 1977)

Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome