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Glutathione STransferase Isozyme Alpha 1 Is Predominantly Involved in the Cisplatin Resistance of Common Types of Solid Cancer

Mech Ageing Dev (2016) 165(Pt B):10714.10.1016/j.mad.2016.12.001 245 ToogoodAAONeillPAShaletSM

This yields the formation of the DNA adducts 4-OHE 2 -1-N7Gua and 4-OHE 2 -1-N3Ade via a Michael addition

Progressive deficiency will lead to mental depression, peripheral neuropathy and fatigue

However, it is important to distinguish between evidence-based medical treatments like tirzepatide and dietary supplements, which are not regulated as pharmaceuticals and lack the same level of clinical validation