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These muscle disabilities were induced by different peripheral causes (e.g., direct muscle, tendon, ligament, and nerve injury [80,81,82,83,84,85,86,87,88,89,90,91], succinylcholine [227], vascular occlusion [228], over-dose of potassium, magnesium or lithium [138,216,229], and tumor cachexia [22])

316 And an extracellular high-glucose environment can drive YAP activity by modifying YAP with O-linked -N-acetylglucosamine

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IV delivery restores it at doses oral supplementation cannot match

Compared with traditional live probiotics, postbiotics offer advantagesdefined composition, improved stability, potentially greater safety, and more tractable mechanisms of actionyet they also have inherent limitations (Table 4

3.3 Targeting cuproptosis to treat OSCC Current therapeutic strategies targeting cuproptosis in OSCC revolve around three main approaches: exploiting copper ionophores, engineering NDDS, and designing combination regimens with conventional therapies