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The lack of this loop in GPX4 is speculated to give GPX4 its unique ability to reduce large and complex substrates such as phospholipid peroxide

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Scalmani, G
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10.1016/j.neubiorev.2015.04.015 [DOI] [PubMed] [Google Scholar] 43.Fernandes BS, Dean OM, Dodd S, Malhi GS, Berk M
as a neuroprotective agent in the Alzheimer disease

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