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Modestly successful results were observed in phase 1 and 2 clinical trials [74]

Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

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Precursors are then transported into cells through unspecific ENTs, such as members of the SLC29A family for NR, while NMN requires dephosphorylation into NR before import into the cell by ENTs 68
