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The resulting iron species (Fe 2+ and Fe 3+ ) directly participate in the Fenton reaction, whereas cisplatin indirectly promotes H 2 O 2 production to accelerate this process, 171 , 172 ultimately generating ROS

Moreover, CDK4/6i have demonstrated limited activity in other types of breast cancer, such as triple negative breast cancer (TNBC), and therapies that sensitise these cancers to CDK4/6i could have substantial utility

Slominski A, Zmijewski MA, Pawelek J

Moreover, resveratrol has been identified as a chemopreventive agent, with extensive experimental efforts focused on understanding this effect