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Our experience shows that understanding these mechanisms is key for any researcher

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However, in the context of elevated vitamin C uptake, high vitamin C can act as a pro-oxidant by reducing iron and promoting lipid peroxidation, GPX4 inactivation, and ferroptotic cell death 125

doi: 10.1016/j.exger.2015.03.004

Depleted glutathione by NAPQI leads to increased H 2 O 2 release that oxidizes thioredoxin and induces the disassociation of thioredoxin from apoptosis signalling-regulating kinase 1 (ASK-1), triggering self-activation of ASK-1, which phosphorylates mitogen-activated protein kinase kinase 4/7 and activates c-Jun N-terminal kinase (JNK) (Hanawa et al., 2008

47,48 GSH metabolism includes degradation and recycling