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Altogether, Pb disrupts not only the presence of essential docking and fusion proteins but also the underlying calcium-dependent signaling that coordinates precise vesicle release, contributing to long-lasting deficits in excitatory neurotransmission

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In this work, we show that ASOs targeting PLN decrease cardiac Pln mRNA expression resulting in significant PLN protein reductions

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In the context of cancer and the TME, LECs, and also BECs, can play a dual role, acting both as facilitators and suppressors of the immune response (21), and displaying a dynamic role on antigen presentation, immune cell trafficking and the modulation of the immune response