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Description
A study found that office-based opioid treatment was associated with improved treatment retention and reduced opioid use compared to traditional opioid treatment programs
Key gap: no human trial has been published, and no human pharmacokinetic study is widely available
doi: 10.3171/jns.1992.77.1.0127
Rotating injection sites helps minimize this
Discontinuation may be warranted if allergic reactions occur, if side effects persist despite slower dosing, or if baseline conditions (acute kidney injury, active infection) change
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