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On the other hand, exosomes from cells with reparative potential, such as bone marrow mesenchymal stem cells (MSCs) or amniotic epithelial cells, have been found to downregulate the pro-ferroptotic lipid metabolism enzyme ACSL4, or upregulate parallel anti-ferroptosis pathways like FSP1/GPX4, thereby attenuating ferroptosis and promoting cartilage repair (Wang Y
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Macabrey D, Longchamp A, MacArthur MR, Lambelet M, Urfer S, Deglise S, et al
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As a secondary effect, it inhibits thalamocortical glutamatergic neurons by inducing cell activation and stimulating the adenylyl cyclase pathway
