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Since Tc52 can inhibit spleen cell proliferation in vitro and the addition of glutathione is able to restore the proliferative response, Tc52 may play an immunosuppressive role as a cysteine and glutathione scavenger both in vitro and in vivo during T

Furthermore, BDNF mRNA accumulates in distal dendrites to activate NMDAR and TrkB receptor (70), the former might have pro-apoptotic excitotoxic activity

Furthermore, it was shown that senolytic vaccination improved normal and pathological phenotypes associated with aging, and extended the male lifespan of progeroid mice (79)

Our findings indicated that ACTL6A is a promising target of GC treatment and give an implication for understanding the mechanisms of metabolic reprogramming and the ferroptosis pathway in GC