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In addition, animal models are often conducted under acute or short-term hypoxic exposure conditions, whereas plateau residents experience long-term chronic hypoxia, a difference that may affect the extrapolation of study results

As the information from other metabolites was available too (choline and creatine), this information was included for complementary purposes and allows comparability with previous observations (Rodrguez-Nieto et al., 2023)

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This can be due to a number of reasons, such as a lack of B12 in the diet, reduced stomach acidity, or when particular cells in the stomach - the "parietal" cells - do not produce enough intrinsic factor