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Consistently, in this study, we observed reduced mRNA levels of antioxidant defense such as sod and nrf2 , along with elevated mRNA levels of keap1 in the liver and muscle of HFD-fed tilapia, indicating the incidence of severe oxidative damage and redox imbalance

Notably, HIF stabilization agents like roxadustat show dual benefits, enhancing endothelial cells' resilience while suppressing pericyte hyperactivation in preclinical models [126]

[DOI] [PMC free article] [PubMed] [Google Scholar] 234.Niesen M, Bedi M, Lopez D
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Cavallini G, Ferraretti AP, Gianaroli L, Biagiotti G, Vitali G
