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Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis

Probing human sperm metabolism using 13 C-magnetic resonance spectroscopy

Chapleau, M., Iaccarino, L., Soleimani-Meigooni, D
Norway: E Vangsy Hansen, Bergen

While hGH has long been viewed as a potential candidate for treating obesity, it can cause side effects such as increases in IGF-1 levels, insulin resistance, and impaired glucose tolerance. By contrast, Fragment 176-191 has no effect on serum IGF-1 levels and no negative effect on carbohydrate metabolism [1]

Digested and alkylated peptides were acidified with 1% TFA, desalted and purified on C18 stage tips for analysis by mass spectrometry
