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The MTHFR enzyme is involved in the formation of SAM, which donates a methyl group for the progression of reactions catalysed by catechol-O-methyltransferase (COMT), an enzyme that participates in hormone regulation, thereby inactivating catechol oestrogens and playing a role in oestrogen metabolism [47]

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Zhang L, Zhang W, Xu H, Liu K

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88 On the other hand, ubiquitin ligases themselves undergo Kla

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