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First, as immunosuppression is expected to be higher in such cases, safety issues should be addressed and avoided

10.1016/0306-4522(87)90015-7 Neuroscience 228 McQuistonA

Inhibiting CypB in tendon appears to impair fibrillogenesis and collagen morphology by altering lysine hydroxylation of collagen molecules, potentially through modulation of LH1-3 selectivity and activity, alteration of the P3H complex, or modification of collagen-SLRP interactions (Kalamajski et al ., 2014

doi: 10.1016/j.jinf.2014.05.014 119 KumarGDagurPKSinghPKShankarHYadavVSKatochVMet al

Due to the challenges associated with directly evaluating individual components of thermoeffector loops, the thermoeffector output-body temperature relationship has been used to infer how various modulators of thermoregulatory control exert their effect on thermoeffector output

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