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Anyone with significant medical conditions, anyone pregnant or breastfeeding, and anyone on multiple medications needs a careful review first not because problems are expected, but because limited human data means we don't assume

Promberger R, Lenglinger J, Riedl O, et al

IGFBPs are also hypothesised to play a role in glucose metabolism

Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604

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