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At the pathophysiological level, two mechanisms underlie the formation of these pigmentations: (i) directly or indirectly inducing the synthesis and release of melanin by melanocytes, resulting in true pigmentation
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Human cytochrome P450 enzyme: a status report summarizing their reactions, substrates, induction, and inhibitors
There was a significant reduction in CK after the rash resolved (mean 264.2 vs 100.1

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