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it is not yet FDA-approved as a standalone medication

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By interacting directly with MAPKs, including c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase 1 (ASK1), GSTs bind the ligand in a complex structure, preventing interactions with their downstream targets [74]

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The complex interplay between glutamine metabolism and cancer progression necessitates a nuanced understanding of the inherent implications of glutamine supplementation on tumor growth, emphasizing the need for comprehensive clinical investigations to delineate its precise role in personalized cancer care [10,19]

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Differences were considered significant if p 3.0.CO;2-T

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