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These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

Our findings demonstrated that 1-DNJ selectively reduces the viability of cancer cells, with a more pronounced effect in glioblastoma cells compared to gastric adenocarcinoma cells

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To determine whether the increase in cell death levels in DADA2 patients cells persisted outside the context of the inflammatory milieu present in vivo, we analysed cell death after increasing incubation times in vitro