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Moreover, the failure in autonomic nerves leads to chronic constipation, reduced distal sweating and dizziness when standing (orthostatic hypotension) due to autonomic neuropathy or dysautonomia

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Plant Physiol 155:218 Foyer CH, Halliwell B (1976) The presence of glutathione and glutathione reductase in chloroplasts: a proposed role in ascorbic acid metabolism

doi: 10.3389/fonc.2021.835141 Received 14 December 2021 Accepted 31 December 2021 Published 11 February 2022 Volume 11 - 2021 Edited by Ashleigh Poh, Olivia Newton-John Cancer Research Institute, Australia Reviewed by Yu-Chan Chang, National Yang-Ming University, Taiwan

303 Additionally, inhibition of mitochondrial respiration failed to rescue the ES/Cu toxicity, 303 and intracellular copper can be released from the ES/Cu complex and become bioavailable outside the mitochondria, suggesting a great likelihood of mitochondrial-independent cuproptosis

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