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The receptors adapt

Interestingly, oxidative stress-mediated S-glutathionylation of PFKFB-3 decreases its catalytic activity in cancer cells, redirecting the glycolytic flux to the PPP (Seo and Lee, 2014)

Available online at: (Accessed June 28, 2025)

J Biochem Chem (1952) 237(10):307781

Several interesting key findings of their study include: a) the cell death induction effect by curcumin was independently through p53 and caspase upregulation, which effectively dodge the atypical stimuli by both p53 and caspase that exert increased the survival and chemoprotection to tumor cells, b) the binding activities of AP-1 and NFB were decreased (where the constitutively over-expression of these genes is a marker in GBM), c) curcumin decreased the expression of genes which conferred chemoresistance such as IAP and Bcl family, and d) the expression of DNA repair enzymes (MGMT, Ku70, Ku80 and DNA-PK cs ) believed to be involved in chemosresistance and radioprotection was inhibited by curcumin