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The empirical solubility measurements showed approximately 102 folds higher aqueous solubility for the glutathione-epothilone conjugate (0.127 mg/ml) compared to unmodified Epothilone (0.00125 mg/ml)

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Abbreviations ECM: Extracellular matrix HDF: Human dermal fibroblasts GR: Glutathione reductase GSH: Glutathione MMP: Matrix metalloproteinase MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide PBS: Phosphate buffered saline ROS: Reactive oxygen species SA- -gal: Senescence-associated -galactosidase UV: Ultraviolet