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Due to this metabolic pathway, treatment with reserpine or tetrabenazine leads to the depletion of brain catecholamines [14]
Our previous work showed that E1 subunit phosphorylation makes a minor contribution to PDHC inhibition in activated macrophages 11 , likely explaining the small portion of PDHC inhibition that cannot be fully recovered by iNOS knockout

Sun ZG, Lian F, Jia Q, Sun JL, Li TT, Guo Y, et al

doi: 10.1016/j.intimp.2022.109574 113 SteitzJWenzelJGaffalETutingT

For the targeted analysis 8 fmol of Cytochrome C digest was added to the samples before injection in LC-MS/MS (Thermo Scientific)
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