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By reserving invasive procedures like ERCP for high-risk therapeutic needs and utilizing non-invasive tools like MRCP for intermediate cases, we protect the patient and the biliary tree

It modulates central appetite and metabolic signaling through presynaptic transporter inhibition and hypothalamic regulation in experimental models

SASP includes pro-inflammatory cytokines (IL-6, IL-8, TNF-), growth factors, and matrix metalloproteinases (MMPs), influencing the tissue microenvironment.19 While SASP plays roles in wound healing and tumor suppression, chronic SASP contributes to inflammation, fibrosis, and aging-related diseases.20 Epigenetic Regulation of Senescence: Chromatin remodeling through histone modifications and DNA methylation influences senescence