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Though allergies to cobalt are rarely dangerous, taking any form of B12 supplement, whether by injection, tablet, or topically applied gel, may result in an uncomfortable, itchy rash

If you suffer from a lack of appetite, you can try to include B12, but even though it is a vitamin, small side effects are a risk in some cases and possibly choosing the injectable version also requires some knowledge

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Many people notice improvements in energy and alertness within a few days, although results can vary depending on individual deficiency levels and overall health

Any supplementation

Ultrapure water (18.2 M cm resistivity, Arium Comfort H2O-I-1-UV-T from Sartorius, Goettingen, Germany) or LC-MS grade water (LiChrosolv, Merck KGaA) was used throughout