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Intervention Strategies to Reduce TMAO Concentrations Changing Dietary Habits TMAO is mainly derived from the gut, and its concentration depends on the type and amount of dietary nutrients consumed (Figure 2)

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J Infect Dis 2002, 185: 868-877
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Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages

It protects the fetus if the mothers diet lacks choline, which was a situation often faced by our ancestors with seasonal deficiencies
