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CFZ is highly lipophilic and is characterized by an unusually long pharmacokinetic half-life of up to 70 days, which is associated with extensive accumulation of the drug in the body [110,111,112]

The most serious side effect is atherosclerosisi , and it is commonly known as carnitine clog

Chin J Integr Med 2013

Moreover, the method of administration (initially parenteral followed by oral in [54] versus oral only in [55]) and length of treatment (4 months in [54] versus 2 months in [55]) were different

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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity