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The MVA pathway is involved in the synthesis of Sec and CoQ10, which are catalytic centers of GPX4 and reducing agents to inhibit lipid peroxidation, respectively

We gratefully acknowledge the Centre National de la Recherche Scientifique (CNRS)-DFG program (EDC) for financial support

2.1 Pathophysiology of Parkinsons disease 2.1.1 Mechanism of neurodegeneration PD is caused by the progressive degradation of dopaminergic nerve cells in the substantia nigra, a part of the brain that is essential for controlling movement (31)

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d , In vitro stability assay of GIPMK-801 ( n = 2) incubated in human plasma or PBS, pH = 7.4 ( n = 1)

Before treatment, we review the full picture