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The disease severity was classified into four grades: healthy (H, green), light symptoms (L, pale green), severe symptoms (S, orange-yellow), or completely dead (D, red)

Moreover, this association was not limited to syngeneic samples, as RNA-Seq of four pairs of unrelated patients biopsies revealed lower expression of at least one of these enzymes in T790M tumours as compared with non-T790M samples (Figure 6e)

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