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Diminished CFTR expression has been observed in spermatozoa from men with various sperm quality abnormalities (teratozoospermia, asthenozoospermia and oligozoospermia), and correlates positively with sperm motility and morphology
These were further chelated by Mn ions for serving as a magnetic resonance imaging (MRI) contrast agent and PEGylated (HMONs-MnPpIX-PEG) [66]

J Dental Res 77:14151425, 1998
When comparing stage 2 siblings, it was identified that Ceruloplasmin (CP), Butyrylcholinesterase (BCHE) and Complement component 7 (C7) were the main additional proteins that aided in differentiating between those affected from those unaffected (Supplementary Fig
10.4291/wjgp.v7.i1.138 49 BraterD

In the next 20 years, there will likely be a 70% increase in the incidence of cancer
