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doi: 10.1016/j.neuropharm.2020.108026 29

Through the layers: how macrophages drive atherosclerosis across the vessel wall

While the study reported positive effects on cerebrospinal fluid biomarkers of neuroinflammation and neurodegeneration, it did not meet its primary clinical efficacy endpoint, highlighting the difficulty of translating biological signals into measurable clinical benefits in a heterogeneous patient population (65)

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