should you refrigerate b12 injections Do need to be refrigerated? B12 Injection Aftercare and Recovery

"Proof of a causative effect of B12 supplements on acne development will require randomized control trials with enough subjects to see a significant effect, if one exists," he told Live Science

Topical applications are often once or twice daily, while injectable protocols might be daily or every other day

This includes confirmed low serum vitamin B12 levels, pernicious anaemia, malabsorption states such as coeliac disease, inflammatory bowel disease, or post-gastric or bariatric surgery, unexplained anaemia, neuropathy or neurological symptoms consistent with vitamin B12 deficiency, a long-term vegan diet with symptoms or low levels, or failure of oral vitamin B12 supplementation

Visible results can last up to six months

Epub 2014 Sep 10

Lifestyle changes (diet and exercise) are essential for sustainable weight loss