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The onset of disease is multifactorial (e.g., a combination of immunogenetic and environmental factors)

Perfil Anti-inflamatrio e Citoprotetor: adequado para investigaes sobre modulao da resposta inflamatria e defesa celular

While PKM2-targeted drug development predominantly centers on cancer metabolic modulation, preliminary investigations have begun exploring its therapeutic potential in neurodegenerative and inflammatory diseases

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

Mitochondrial dysfunction further exacerbates oxidative stress by impairing ATP production and damaging mitochondrial DNA, leading to compromised sperm motility and energy deficits

Yang H, Tabe Y, Sekihara K, Saitoh K, Ma H, Ruvolo V, Imoto J, Ikeo K, Mogushi K, Hosoya M, Hayashizaki Y, Yamanaka Y, Miida T, Andreeff M , Marszalek JR, Konopleva M