foxo4-dri senolytic 2024 animal model Peptide inhibitors targeting FOXO4-p53 interactions and inducing senescent cancer cell-specific apoptosis Senotherapy for chronic lung disease

10.1038/s41591-019-0375-9 Nat

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Abstract Chronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal neurodegeneration, for which the underlying mechanism remains poorly understood

Losing weight alone does not appear to account for its wide-ranging metabolic effects