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For example the use of vitamin B12 for correct reasons improved by 10% (62% in phase 1 to 72% In phase 2) resulting in a 32% reduction in the number of patients inappropriately receiving it (521 to 352)

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Obese individuals under medication to control gastroesophageal reflux also may report vitamin B12 deficiency

Also this structure is related to the dopamine and serotonin interaction with the opioidergic system (31, 32)