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Funding This research was supported by the Natural Science Foundation of China (32202641, 32460819, 31960672), the Natural Science Foundation of Ningxia (2025AAC030558, 2025AAC040003), the Central Guidance on Local Science and Technology Development Fund (2024FRD05052) and the Key R & D projects in Ningxia Hui Autonomous Region (2024BBF01007 & 2023BCF01006)
Zito PM, Bistas KG, Syed K
The suppressed neuro-inflammatory response in the prefrontal cortex (PFC) and HIP was observed, evidenced by reduced NF-kB, p38, and JNK concentrations in the CoQ 10 groups (Salehpour et al., 2019)
Chondroprotective Effects of Copper in Cartilage Copper, an essential redox-active trace element, which is essential for most aerobic organisms (Tapiero et al., 2003

This means that pepsin can inflict damage even in non-acidic environments (Reference Kowalik and Krzeski28)

10.1186/s12933-017-0496-8 33 JiangX.HuangX.TongY.GaoH