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Hexachlorophene was an extensively used bisphenol that was mainly applied as an antiseptic agent in personal care products (Marzulli and Bruch, 1981) until concerns over its neurotoxicity led to it being banned in the US in 1970s (Heidler and Halden, 2009)

In conclusion, in this review, we briefly describe the mitochondrial structure, summarize the specific regulatory mechanisms of the mitochondrial quality control system and the interaction between various pathways, and finally elaborate the research progress of mitochondrial biogenesis, mitophagy and mitochondrial dynamics in several common neurodegenerative diseases, in order to understand more about the mitochondrial quality control system and provide new research targets and ideas for the treatment of neurodegenerative diseases