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Science 302 , 17601765 (2003)

doi: 10.3390/ijms25073983 85 YaoMMaJWuDFangCWangZGuoTet al

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There, HIF- subunits dimerize with aryl hydrocarbon receptor nuclear translocator, recruit transcriptional coactivators such as p300/CBP, and bind to hypoxia-responsive elements in target genes to activate transcription

SIRT1 can bind and retain GAPDH in the cytosol, but SIRT5 actives GAPDH via demalonylation, thereby elevating glycolytic flux