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Lippincott Williams and Wilkins, New York, 1999, pp

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In fact, a key parameter omitted in the trials with deferiprone was that the iron chelator was not targeted to the mitochondria, so effectively only a small fraction of the compound delivered would accumulate in the principal site of damage under these conditions

J.RigattiP.Van PoppelH.et al (2013)

Approximately 80% of people with MS experience fatigue, with 50% to 60% considering it their most disabling symptom

Paroxetine increases the activity of complexes I and II in the hippocampus, striatum, and cortex, whereas venlafaxine selectively enhances complex II activity across these regions and complex IV activity in the prefrontal cortex [122]