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Predrag Sikiric and colleagues at the University of Zagreb, BPC-157 has been in active pre-clinical research since the early 1990s accumulating one of the most extensive and diverse research profiles of any peptide compound in regenerative biology

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reported that HIF-1 can regulate the malignant progression of GBM under hypoxic conditions and that hyperbaric oxygen significantly inhibits HIF-1 expression, increasing the sensitivity of GBM cells to chemotherapy (113)

Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH (2010) Endurance training enhances BDNF release from the human brain