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1) Oxidative block irreversible, makes NADPH and CO Step 1: G6P + NADP 6-phosphogluconolactone + NADPH via G6PD (rate-limiting) Step 2: lactone + HO 6-phosphogluconate Step 3: 6-PG + NADP ribulose-5-P (Ru5P) + CO + NADPH Net per G6P: 2 NADPH + CO + Ru5P 2) Non-oxidative block reversible sugar shuffling Ru5P ribose-5-P (R5P) or xylulose-5-P (Xu5P) Transketolase (TPP-dependent) moves 2-carbon pieces: Xu5P + R5P sedoheptulose-7-P + GAP

(PubMed) Annweiler C, Schott AM, Allali G, et al

This is where the concept of bioavailability becomes critical

Trong lm p, n c bit nh kh nng lm sng da t bn trong, gim nm, tn nhang v vt thm da u mu hn

This phenomenon has been noted in several regions, including the Red River Delta in Vietnam, the Mekong Basin in Cambodia and Vietnam, the Terai Belt in Nepal, and the Bengal Basin in India, Bangladesh, and Pakistan

After 24 h, the medium was replaced and the cells incubated for 6 or 24 h with the tested complexes