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Treatment that is Not Effective Treatment of Single-Dose Doxycycline (Cameron, D, Expert Rev Anti-Infect Ther 2014) Misses early disease especially if no EM rash 6-week observation of symptoms may exacerbate late disease Efficacy = 50% May lead to seronegative Lyme disease later Topical, long-acting or multi-dose treatment thats less than 21 days fails to show advocacy in human trials (Zeidner NS

doi: 10.3390/pharmaceutics14051079 20 CordeiroD.SternT.SternS

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[DOI] [PubMed] [Google Scholar] 45.Sterling S.R., Bowen S.A