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Abbreviations LC L-carnitine TC Total carnitine TMAO Trimethylamine-N-oxide CHO Carbohydrates IGF-1 Insulin-like growth factor-1 PI3K Phosphoinositide-3-kinase Akt Protein kinase B mTOR Mammalian target of rapamycin S6K S6 kinase 4E-BP 4E-binding protein FoxO Forkhead box O MuRF-1 Muscle-specific RING finger-1 atrogin-1 Muscle atrophy F-box mRNA Messenger RNA BMI Body mass index ROS Reactive oxygen species Authors contributions Conceptualization: R.O

Experimental results from in vitro and in vivo studies found no evidence of LC toxicity (Rebouche, 2004)

Rial NS, Meyskens FL, Gerner EW

Kohlenhydrate sorgen fr eine leichte Insulinausschttung

Secondary endpoints At 12 months after baseline 7 not treated subjects (16.7%) were self-sufficient, as compared to 2 (4.7%) treated subjects ( p = 0.0719, adj

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