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Its ability to influence gene expressionreportedly altering the activity of thousands of genesprovides a powerful model for investigating how cellular function can be modulated towards a regenerative state

doi: 10.1016/S2352-3026(19)30249-2 18 BenoitSWKhandelwalPGrimleyMS

82 They also observed that in primary BM samples from MM patients, isatuximab significantly depleted tumor plasma cells, CD38 hi Blymphocyte precursors, basophils, and NK lymphocytes

No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

doi: 10.1111/j.1527-5299.2005.03827.x
