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First, ROS directly modifies ion channels, oxidizing sulfhydryl groups on voltage-gated Na+ channels, resulting in abnormal action potential propagation and contributing to the paradoxical coexistence of pain and numbness (Elafros et al., 2022)

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Because no preservatives other than bacteriostatic water are present, sterility and potency beyond the recommended usage period cannot be guaranteed

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Numerous natural products and TCM formulations have been investigated for potential therapeutic applications acting through these signaling pathway regulatory mechanisms (Wang et al., 2024)

Their prohibited products policy is more nuanced than Shopify's, allowing certain gray-area products when sellers demonstrate legal compliance