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However, high risk patients (advanced PD, diabetic patients, subclinical PN) who are considered as more prone to developing symptomatic PN should receive regular injections of Vit B12 and B6 (Uncini et al

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Antioxid Redox Signal 15:343352

However, in the 1980s, it was discovered that certain positively charged platinum compounds that can only bind to DNA at one site have anti-cancer activity, rekindling interest in them

Additional conditions under the umbrella of congenital IGF-1 deficiencies include a documented case of a 15-year-old boy suffering from severe prenatal and postnatal growth failure, sensorineural deafness and mental retardation due to a homozygous partial deletion of the IGF-I gene [41] as well as IGF1R genes defects [42]